Fig. 6
From: OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
OTUD5 deubiquitinates and stabilizes SLC38A1 in HCC cells. (A) HCCLM3 cells with OTUD5 knockdown were treated with or without MG132. The downregulation of SLC38A1 protein induced by OTUD5 knockdown was reversed by MG132. (B and C) OTUD5 knockdown shortened and OTUD5 overexpression prolonged the half-life of the SLC38A1 protein in HCC cells. (D and E) OTUD5 knockdown promoted but OTUD5 overexpression suppressed the ubiquitination of OTUD5 in HCC cells. *P < 0.05